GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs10935120 | 1 | rs6787371 | chr3:134254991 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.76 | 1.02E-7 | Height |
| THYM | cis | rs9815354 | 1 | rs6789260 | chr3:41776350 | ULK4 | chr3:41288091-42003660:- | 0.98 | 9.44 | 2.56E-15 | Diastolic blood pressure |
| THYM | cis | rs10935120 | 1 | rs6790466 | chr3:134197740 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 7.97 | 3.55E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs6790466 | chr3:134197740 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.69 | 1.38E-7 | Height |
| THYM | cis | rs9815354 | 1 | rs6790732 | chr3:41864872 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs6791806 | chr3:41889995 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs7608910 | 1 | rs67927699 | chr2:61187415 | C2orf74 | chr2:61372243-61391964:+ | 0.38 | 4.27 | 4.62E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THYM | cis | rs10935120 | 1 | rs6793487 | chr3:134299426 | ANAPC13 | chr3:134196547-134204865:- | -0.57 | -7.56 | 2.56E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs6793487 | chr3:134299426 | CEP63 | chr3:134204575-134293852:+ | -0.42 | -6.07 | 2.66E-8 | Height |
| THYM | cis | rs9876781 | 1 | rs6794875 | chr3:48455626 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.34 | 3.54E-5 | Longevity |
| THYM | cis | rs9815354 | 1 | rs6796210 | chr3:41851718 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs6796491 | chr3:48430465 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.02E-5 | Longevity |
| THYM | cis | rs9815354 | 1 | rs6797165 | chr3:41887777 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs1401999 | 1 | rs6800217 | chr3:183685893 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.28 | 4.53E-5 | Anterior chamber depth |
| THYM | cis | rs10935120 | 1 | rs6800862 | chr3:134228628 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.61 | 1.94E-11 | Height |